An abundance of information about lung development in animal models exists; however, comparatively little is known about lung development in humans. Recent advances using primary human lung tissue combined with the use of human in vitro model systems, such as human pluripotent stem cell‐derived tissue, have led to a growing understanding of the mechanisms governing human lung development. They have illuminated key differences between animal models and humans, underscoring the need for continued advancements in modeling human lung development and utilizing (...) human tissue. This review discusses the use of human tissue and the use of human in vitro model systems that have been leveraged to better understand key regulators of human lung development and that have identified uniquely human features of development. This review also examines the implementation and challenges of human model systems and discusses how they can be applied to address knowledge gaps. (shrink)

For most of its career philosophy of religion has been a controversial dis cipline: it has usually ended up becoming a substitute for what it set out to explain. Born out of the religious scepticism of the late seventeenth century it remained for many years what it was to Hume and Lessing: an instrument for criticizing rather than for interpreting faith. Gradually the hostility subsided, but not the tendency to reduce. Nearly each one of the great names in this area (...) represents a theory that goes "beyond" faith. Phenomenology changed that situation. Conceived for accurate under standing of acts and meanings rather than for the building of vast synthe ses, its method was more apt to yield understanding than criticism. Moreover, by distinguishing the ideal meanings from the psychic realities of the act, it chased its followers from the quagmire of psychic genesis, causal justification and rational "proof" of the religious object, and forced them to concentrate on the intentional terminus of the experience. (shrink)

For most of its career philosophy of religion has been a controversial dis cipline: it has usually ended up becoming a substitute for what it set out to explain. Born out of the religious scepticism of the late seventeenth century it remained for many years what it was to Hume and Lessing: an instrument for criticizing rather than for interpreting faith. Gradually the hostility subsided, but not the tendency to reduce. Nearly each one of the great names in this area (...) represents a theory that goes "beyond" faith. Phenomenology changed that situation. Conceived for accurate under standing of acts and meanings rather than for the building of vast synthe ses, its method was more apt to yield understanding than criticism. Moreover, by distinguishing the ideal meanings from the psychic realities of the act, it chased its followers from the quagmire of psychic genesis, causal justification and rational "proof" of the religious object, and forced them to concentrate on the intentional terminus of the experience. (shrink)

Widely acknowledged as the principal architect of Scottish common sense philosophy, Thomas Reid is increasingly recognized today as one of the finest philosophers of the eighteenth century. Combining a sophisticated response to the skeptical and idealist views of his day, Reid's thought stands as an important alternative to Humean skepticism, Kantian idealism and Cartesian rationalism. This volume is the first comprehensive overview of Reid's output and covers not only his philosophy in detail, but also his scientific work and his extensive (...) historical influence. (shrink)

Erasmus wrote his Colloquies as educational material for training boys in Latin conversation. This volume of the Amsterdam edition of the Latin texts of Erasmus offers a critical edition of the Latin texts of these influential, creative writings, which resemble short Latin plays.

Escritos por onze renomados filósofos os ensaios pretendem, de forma acessível e didática, explicitar as principais tendências e perspectivas da reflexão ética contemporânea. Indicado a estudantes e docentes de filosofia ética, teologia, sociologia e interessados em geral. -/- Prefàcio 1.Tendencias neoaristotelicas na etica atual - Sergio Cremaschi 2. Alasdair MacIntyre e o retorno as tradicoes morais de pesquisa racional - Helder Buenos Aires de Carvalho 3. Etica da finitude - Zeljko Loparic 4. Por uma etica ilustrada e progressista: uma defesa (...) do utilitarismo - Maria Cecilia Maringoni de Carvalho 5. A relacao da filosofia analitica com a teologia moral - Terence Kennedy 6. Rawls: uma teoria etico-politica da justica - Sonia T. Felipe 7. Etica do discurso - F. Javier Herrero 8. Hans Jonas: o principio responsabilidade - Oswaldo Giacoia Junior 9. Etica de coerencia dialetica - Carlos Cirne-Lima 10. Etica intencionalista-teleologica em vittorio hosle - Manfredo Araujo de Oliveira. (shrink)

Although the evidence remains tentative at best, the conception of hallucinations in schizophrenia as being underconstrained perception resulting from intrinsic thalamocortical resonance in sensory areas might complement current models of hallucination. However, in itself, the approach falls short of comprehensively explaining the neurogenesis of hallucinations in schizophrenia, as it neglects the role of external attributional biases, mental imagery, and a disconnection between frontal and temporal areas.

Previous research in North America has supported the view that male involvement in committed, romantic relationships is associated with lower testosterone (T) levels. Here, we test the prediction that undergraduate men involved in committed, romantic relationships (paired) will have lower T levels than men not involved in such relationships (unpaired). Further, we also test whether these differences are more apparent in samples collected later, rather than earlier, in the day. For this study, 107 undergraduate men filled out a questionnaire and (...) collected one saliva sample (from which a subject’s T level was measured) at various times across the day. As in previous studies, men involved in committed, romantic relationships had lower salivary T levels, though only during later times of the day. Furthermore, additional analysis of the variation among unpaired subjects indicated that men without prior relationship experience had lower T levels than experienced men. Finally, while paired men as a group had lower T levels than unpaired men, those men at the earliest stage (less than six months) of a current relationship had higher T levels than unpaired men as well as men in longer-term relationships. These results suggest that variation in male testosterone levels may reflect differential behavioral allocation to mating effort. (shrink)

Music can reduce stress and anxiety, enhance positive mood, and facilitate social bonding. However, little is known about the role of music and related personal or cultural variables in maintaining wellbeing during times of stress and social isolation as imposed by the COVID-19 crisis. In an online questionnaire, administered in 11 countries, participants rated the relevance of wellbeing goals during the pandemic, and the effectiveness of different activities in obtaining these goals. Music was found to be the most effective activity (...) for three out of five wellbeing goals: enjoyment, venting negative emotions, and self-connection. For diversion, music was equally good as entertainment, while it was second best to create a sense of togetherness, after socialization. This result was evident across different countries and gender, with minor effects of age on specific goals, and a clear effect of the importance of music in people's lives. Cultural effects were generally small and surfaced mainly in the use of music to obtain a sense of togetherness. Interestingly, culture moderated the use of negatively valenced and nostalgic music for those higher in distress. (shrink)

The hexagonal structure for ‘the geometry of logical opposition’, as coming from Aristoteles–Apuleius square and Sesmat–Blanché hexagon, is presented here in connection with, on the one hand, geometrical ideas on duality on triangles (construction of ‘companion’), and on the other hand, constructions of tripartitions, emphasizing that these are exactly cases of borromean objects. Then a new case of a logical interest introduced here is the double magic tripartition determining the semi-ring ${\mathcal{B}_3}$ and this is a borromean object again, in the (...) heart of the semi-ring ${{\rm Mat}_{3}(\mathbb{B}_{\rm Alg})}$ . With this example we understand better in which sense the borromean object is a deepening of the hexagon, in a logical vein. Then, and this is our main objective here, the Post-Mal’cev full iterative algebra ${\mathbb{P}_4 = \mathbb{P}(\mathbb{F}_4)}$ of functions of all arities on ${\mathbb{F}_4}$ , is proved to be a borromean object, generated by three copies of ${\mathbb{P}_2}$ in it. This fact is induced by a hexagonal structure of the field ${\mathbb{F}_4}$ . This hexagonal structure is seen as precisely a geometrical addition to standard boolean logic, exhibiting ${\mathbb{F}_4}$ as a ‘boolean manifold’. This structure allows to analyze also ${\mathbb{P}_4}$ as generated by adding to a boolean set of logical functions a very special modality, namely the Frobenius squaring map in ${\mathbb{F}_4}$ . It is related to the splitting of paradoxes, to modified logic, to specular logic. It is a setting for a theory of paradoxical sentences, seen as computations of movements on the bi-hexagonal link among the 12 classical logics on a set of 4 values. (shrink)

Plato's Euthyrphro, Apology, andCrito portray Socrates' words and deeds during his trial for disbelieving in the Gods of Athens and corrupting the Athenian youth, and constitute a defense of the man Socrates and of his way of life, the philosophic life. The twelve essays in the volume, written by leading classical philosophers, investigate various aspects of these works of Plato, including the significance of Plato's characters, Socrates's revolutionary religious ideas, and the relationship between historical events and Plato's texts.

The excellent quality and depth of the various essays make [the book] an invaluable resource....It is likely to become essential reading in its field.—CHOICE.

Spade 1988 sugges t s tha t t he r e are ac tua l l y two theo r i e s t o address t h i s ques t i o n t o , an ear l y one and a l a t e r one . 2 Most o f the presen t pape r i s a deve l o pmen t o f t h i s i dea . I sugges t (...) tha t ear l y work by Sherwood and o the r s was a s tudy o f quan t i f i e r s : the i r semant i c s and t he e f f e c t s o f con t e x t on i n f e r e n ce s t ha t can be made f r om quan t i f i e d te rms . La te r , i n the hands o f Bur l e y and o the r s , i t changed i n t o a s tudy o f someth i n g e l se , a s tudy o f what I ca l l g loba l quan t i f i c a t i o n a l e f f e c t . In sec t i o n 1 , I exp l a i n what these two op t i o n s are. (shrink)

This paper observes that P. F. Strawson’s distinction between descriptive and revisionary metaphysics is a baffling one from the perspective of traditional metaphysics. If one thinks of metaphysics as the study of the fundamental nature of reality, it is bewildering to divide up metaphysics in this way. The paper then tries to show how the distinction is no longer bewildering if we deny that such study is possible.

It is often repeated that at the unsuccessful productions of Terence's Hecyra the audience left the theatre in order to see, on the first occasion, boxers and a tight-rope walker, on the second, a gladiatorial contest.1 The other view, that the spectators remained but demanded other entertainment, is to my mind clearly correct and deserves restatement since the mistaken one is so widespread.

En 1893, « physicien-ingénieur » André Blondel invente l’oscillographe bifilaire permettant de visualiser les tensions et courants variables. À l’aide de ce puissant moyen d’investigation, il entreprend tout d’abord l’étude des phénomènes de l’arc électrique alors utilisé pour l’éclairage côtier et urbain puis de l’arc chantant employé comme émetteur d’ondes radioélectriques en T.S.F. En 1905, il met en évidence un nouveau type d’oscillations non-sinusoïdales au sein de l’arc chantant. Vingt ans plus tard, Balthasar Van der Pol reconnaitra qu’il s’agissait en (...) réalité d’oscillations de relaxation. Pour expliquer ce phénomène, il fait appel à une representation dans le plan de phase et montre que son évolution prend la forme de petits cycles. Pendant le premier conflit mondial la triode remplace peu à peu l’arc chantant dans les systèmes de transmission. Au sortir de la guerre, Blondel transpose à la triode la plupart de ses résultats par analogie avec l’arc chantant. En avril 1919, il publie un long mémoire dans lequel il introduit la terminologie « oscillations auto- entretenues » et propose d’illustrer ce concept à partir de l’exemple du vase de Tantale qui sera ensuite repris par Van der Pol et par Philippe Le Corbeiller. Il fournit alors une définition d’un système auto-entretenu assez proche de celles qui seront données par la suite par Aleksandr’ Andronov et Van der Pol. Pour étudier la stabilité des oscillations entretenues par la triode et par l’arc chantant il utilise cette fois une représentation dans le plan complexe et explicite l’amplitude en coordonnées polaires. Il justifie alors l’entretien des oscillations par l’existence de cycles qui présentent presque toutes les caractéristiques des cycles limites de Poincaré. Enfin, en novembre 1919, Blondel réalise, un an avant Van der Pol, la mise en équation des oscillations d’une triode. En mars 1926, Blondel établit l’équation différentielle caractérisant les oscillations de l’arc chantant, en tous points similaire à celle qu’obtient concomitamment Van der Pol pour la triode. Ainsi, tout au long de sa carrière, Blondel, a apporté une contribution fondamentale et relativement méconnue à l’élaboration de la théorie des oscillations non linéaires. L’objet de cet article est donc d’analyser ses principaux travaux dans ce domaine et de mesurer leur importance, voire leur influence en les replaçant dans la perspective du développement de cette théorie. (shrink)

This paper evaluates the following argument, suggested in the writings of Donald Davidson: if there is such a thing as the given, then there can be alternative conceptual schemes; there cannot be alternative conceptual schemes; therefore there is no such thing as the given.

There is an intuition that the past does not ever change. In their paper ‘The puzzle of the changing past,’ Luca Barlassina and Fabio Del Prete argue that in 2012 the past changed. I show that we are not in a position to accept their argument.

In lieu of an abstract, here is a brief excerpt of the content:Eating Disorders and Mimetic Desire René Girard Stanford University Among younger women, eating disorders are reaching epidemic proportions. The most widespread and spectacular at this moment is the most recently identified, the so-called bulimia nervosa, characterized by binge eating followed by "purging," sometimes through laxatives or diuretics, more often through self-induced vomiting. Some researchers claim that, in American colleges, at least one third of the female student population (...) is involved to some degree. (Since nine out of ten sufferers are women I will use feminine pronouns in this paper but some undergraduates at Stanford tell me that the epidemic is spreading to male students.) G.M.F. Russell, the first researcher who focused on the specific aspects ofmodern bulimia, is usually presented as the discoverer of a new illness. The title ofhis 1979 publication contradicts this view: "Bulimia Nervosa: An Ominous Variant ofAnorexiaNervosa." And, indeed, all the symptoms he describes had been mentioned before in connection with anorexia (see Bruch). The insurance companies and the medical profession like only welldefined illnesses, and so does the public. We all try to distance ourselves from pathological contamination by giving it a name. Eating disorders are often discussed as ifthey were new varieties ofmeasles or oftyphoid fever. Why distrust the distinction between two illnesses with symptoms as radically opposed as those of anorexia and bulimia? Because we live in a world where eating too much and not eating enough are opposite but inseparable ways ofcoping with the slenderness imperative that dominates 2 René Girard our collective imaginations. Most of us oscillate all our lives between attenuated forms ofthese two pathologies. The man in the street understands perfectly a truth that most specialists prefer not to confront. Our eating disorders are caused by our compulsive desire to lose weight. Most books on the subject acknowledge the universal calorie phobia but somewhat absent-mindedly, as if it could not be the major cause ofa serious illness. How could a fundamentally healthy desire become the cause ofpathological behavior, even ofdeath? Many people would be healthier, no doubt, ifthey ate less. In view of this fact, it is not illogical to suppose that, in anorexia, there must be some motivation other than this healthy desire, some unconscious drive, no doubt, that generates abnormal behavior. By turning anorexia and bulimia into two separate pathologies, the classificators make it easier for us to lose sight of their common basis. The bankruptcy of modern theories The search for hidden motivations is the alpha and omega, ofcourse, of our modern culture. Our number one principle is that no human phenomenon is really what it seems to be. A satisfactory interpretation must rely on one of the hermeneutics of suspicion that have become popular in the nineteenth and twentieth century, or on several ofthese, on a cocktail of soupçon: psychoanalysis, Marxism, feminism, etc. We automatically assume that social phenomena have little if anything to do with what is obvious in them, in this case the rejection offood. In anorexia, psychoanalysts usually diagnose "a refusal of normal sexuality," due to the patient's excessive desire "to please her father," etc. These explanations are still invoked in books being written right now but the voice is growing fainter. Around this sort of thing the smell of mustiness is overpowering. Even in Lacan's own land, the old arrogance is gone. Early in my life, I had an opportunity to observe that the eating practices ofyoung women have nothing to do with a desire to please their fathers. Just before World War II, a pretty cousin of mine was dieting furiously and her father, my uncle, was storming about helplessly, trying to get her to eat more. Fathers, as a rule, are not pleased to see their daughters starve themselves. This particular father was also a physician, at a time when the medical profession had not yet caught the disease it was already trying to cure. Eating Disorders andMimetic Desire3 This uncle was our family doctor and, as such, had great prestige in my eyes, at least until that day. I had not yet read Freud but my later skepticism regarding his conception offatherhood may well originate in this incident. I immediately... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Eating Disorders and Mimetic Desire René Girard Stanford University Among younger women, eating disorders are reaching epidemic proportions. The most widespread and spectacular at this moment is the most recently identified, the so-called bulimia nervosa, characterized by binge eating followed by "purging," sometimes through laxatives or diuretics, more often through self-induced vomiting. Some researchers claim that, in American colleges, at least one third of the female student population (...) is involved to some degree. (Since nine out of ten sufferers are women I will use feminine pronouns in this paper but some undergraduates at Stanford tell me that the epidemic is spreading to male students.) G.M.F. Russell, the first researcher who focused on the specific aspects ofmodern bulimia, is usually presented as the discoverer of a new illness. The title ofhis 1979 publication contradicts this view: "Bulimia Nervosa: An Ominous Variant ofAnorexiaNervosa." And, indeed, all the symptoms he describes had been mentioned before in connection with anorexia (see Bruch). The insurance companies and the medical profession like only welldefined illnesses, and so does the public. We all try to distance ourselves from pathological contamination by giving it a name. Eating disorders are often discussed as ifthey were new varieties ofmeasles or oftyphoid fever. Why distrust the distinction between two illnesses with symptoms as radically opposed as those of anorexia and bulimia? Because we live in a world where eating too much and not eating enough are opposite but inseparable ways ofcoping with the slenderness imperative that dominates 2 René Girard our collective imaginations. Most of us oscillate all our lives between attenuated forms ofthese two pathologies. The man in the street understands perfectly a truth that most specialists prefer not to confront. Our eating disorders are caused by our compulsive desire to lose weight. Most books on the subject acknowledge the universal calorie phobia but somewhat absent-mindedly, as if it could not be the major cause ofa serious illness. How could a fundamentally healthy desire become the cause ofpathological behavior, even ofdeath? Many people would be healthier, no doubt, ifthey ate less. In view of this fact, it is not illogical to suppose that, in anorexia, there must be some motivation other than this healthy desire, some unconscious drive, no doubt, that generates abnormal behavior. By turning anorexia and bulimia into two separate pathologies, the classificators make it easier for us to lose sight of their common basis. The bankruptcy of modern theories The search for hidden motivations is the alpha and omega, ofcourse, of our modern culture. Our number one principle is that no human phenomenon is really what it seems to be. A satisfactory interpretation must rely on one of the hermeneutics of suspicion that have become popular in the nineteenth and twentieth century, or on several ofthese, on a cocktail of soupçon: psychoanalysis, Marxism, feminism, etc. We automatically assume that social phenomena have little if anything to do with what is obvious in them, in this case the rejection offood. In anorexia, psychoanalysts usually diagnose "a refusal of normal sexuality," due to the patient's excessive desire "to please her father," etc. These explanations are still invoked in books being written right now but the voice is growing fainter. Around this sort of thing the smell of mustiness is overpowering. Even in Lacan's own land, the old arrogance is gone. Early in my life, I had an opportunity to observe that the eating practices ofyoung women have nothing to do with a desire to please their fathers. Just before World War II, a pretty cousin of mine was dieting furiously and her father, my uncle, was storming about helplessly, trying to get her to eat more. Fathers, as a rule, are not pleased to see their daughters starve themselves. This particular father was also a physician, at a time when the medical profession had not yet caught the disease it was already trying to cure. Eating Disorders andMimetic Desire3 This uncle was our family doctor and, as such, had great prestige in my eyes, at least until that day. I had not yet read Freud but my later skepticism regarding his conception offatherhood may well originate in this incident. I immediately... (shrink)

En primer término se analiza brevemente el contexto que posibilita en García Lorca la búsqueda de un nuevo lenguaje poético durante su estadía en Nueva York entre 1929-1930. Posteriormente se analiza el concepto de flâneur. Para ello se consideran las elaboraciones que desarrolló Walter Benjamin a propósito de la experiencia de Charles Baudelaire frente a las transformaciones urbanas y sociales que sufrió París a mediados del siglo XIX, durante el Segundo Imperio en Francia. Finalmente se indaga en la eventual configuración (...) de la figura del flâneur en Poeta en Nueva York de Federico Garcia Lorca. First of all, it’s analyzed briefly the context that makes possible in García Lorca the search of a new poetic language during his stay in New York between 1929 and 1930. Subsequently it’s analyzed the concept of flâneur. Because of that, it must be taken into account the devise that Walter Benjamin explained according to Charles Baudelaire’s experience against the urban and social transformations that hit Paris in the 19th century during the Second French Empire. Finally it makes inquiries in the possible configuration of the flâneur in Poeta en Nueva York by Federico García Lorca. (shrink)

Si vous avez un jour hésité entre « F » et « M » en remplissant un formulaire, si enceinte de plus de huit mois et entrant dans un taxi on vous a appelé « Monsieur », si votre attirance pour le « sexe opposé » vous semble au contraire relever bizarrement davantage de l’homosexualité que de l’hétérosexualité, et si en plus vous êtes intéressé par les choses du corps, de la biologie et de la génétique, alors vous serez passionné (...) par cet ouvrage. Mais si vous vivez votre sexe physique et votre g... (shrink)